UDK 616-006
BBK 55.6
T92

Editors

Dr. sci. (med.) Sergej OSINSKY

Professor of Oncology, Department of Microenvironment of Tumor Cells,
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology
National Academy of Sciences of Ukraine, Kiev, Ukraine

Dr. med. Helmut FRIESS

Professor and Chairman, Department of Surgery, Klinikum rechts der Isar,
Technische Universitat Munchen, Munich, Germany

Dr. med. Peter VAUPEL, M.A., Univ. Harvard

Professor of Tumor Pathophysiology, Department of Radiotherapy and

Radiooncology, Klinikum rechts der Isar, Technische Universitat Munchen,
Munich, Germany

Reviewers

Academician of NAS of Ukraine V.F. CHEKHUN, academician of NAS of Ukraine A.A. MOJBENKO

Editorial assistances

Dr. D. K. Kelleher, Ph.D., University of Mainz, Germany and Dr. M. Zavelevich, Ph.D., R.E. Kavetsky Institute of Experimental Pathology, Oncology and
Radiobiology, Kiev, Ukraine

The monograph is published in accordance with recommendation of the Scientific Board of R.E. Kavetsky Institute of Experimental Pathology,
Oncology and Radiobiology (N° 8, 03 June, 2010).
Publication was made possible by a State contract promoting the production of scientific printed material.

T92

Tumor hypoxia in the clinical setting / S. Osinsky, H. Friess, P. Vaupel
(eds.). — K.: Akademperiodyka, 2011. — 272 p., 8 p. il.

ISBN 978-966-360-169-4

This monograph considers the data from pathophysiological studies of human tumors, in particular concerning the pathogenesis of tumor hypoxia and the molecular basis of its
impact on tumor aggressiveness. Special attention has been paid to the relevance of tumor hypoxia for diagnosis and treatment, as well as for the prognosis of disease outcome. Tumor
response to treatment and approaches to enhance its efficacy are considered, with special emphasis on the role played by intratumorai hypoxia. The link between the molecular mecha-
nisms of malignant growth and the pathophysiological characteristics of neoplasia is discussed using the example of human tumors.