Gluzman D.F., Sklyarenko L.M., Koval S.V., Ivanovskaya T.S., Zavelevich M.P., Philchenkov A.A., Polischuk A.S., Rodionova N.K. Modern classification and diagnosis of myelodysplastic syndromes. Scientific-and-methodical guide

book 13 cover

Myelodysplastic syndromes (MDS) represent the heterogeneous group of clonal malignancies resulting from the proliferation of the abnormal hematopoietic stem cells or closely related progenitor cells that is characterized by ineffective hematopoiesis, dysplasia involving one or several lineages of myelopoiesis, and the increased risk of transformation into acute myeloid leukemia.

The scientific-and-methodical guide discloses the historical aspects of MDS, the epidemiological data on the incidence and mortality, the adverse factors pertaining to the MDS origin. Furthermore, the molecular-and-genetic mechanisms of pathogenesis including the role of hematopoietic microenvironment and the impairment of apoptosis are focused on.

The basics of the laboratory diagnosis of the various forms of MDS in accordance with the up-todate classifications are considered.

The guidebook is intended for the physicians specializing in hematology and oncology, for clinical laboratory technicians, pathologists and cytologists. The book will be also useful for medical students and those taking the advanced training courses.


ISBN 978-617-696-776-7

© D.F. Gluzman, L.M. Sklyarenko, S.V. Koval, T.S. Ivanovskaya, M.P. Zavelevich, A.A. Philchenkov, A.S. Polischuk, N.K. Rodionova, 2018

 

Contents

  • List of abbreviations
  • MDS definition
  • Historical aspects and systematization of MDS
  • Epidemiological data on MDS incidence
  • Possible role of environmental risk factors for MDS
  • Ionizing radiation and MDS
  • Secondary MDS
  • Criteria for MDS diagnosis
  • New classification of MDS (WHO 2016)
  • Clinical presentation of MDS
  • Results of cytomorphological examination of blood and bone marrow
  • Histological study of bone marrow biopsies
  • Differential diagnosis
  • Dysplastic alterations in cells of various lineages of myelopoiesis
  • Immunophenotypic markers of aberrant stem cells in MDS
  • Impairment of immunological mechanisms controlling stem cells in MDS
  • Cytogenetic abnormalities in MDS
  • Mutations in hematopoietic stem cells and progenitor cells in MDS
  • Apoptosis alterations in MDS
  • Microenvironment and its interplay with the pathological clones of cells in MDS
  • Systems for predicting MDS course
  • MDS in Ukraine (according to the data of Reference Laboratory of RE Kavetsky IEPOR, NAS of Ukraine)
  • MDS in children
  • Reference list
  • Annex 1
  • Annex 2
  • Winduza. Prescribing information
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