Vasyl F. Chekhun

chekhun v-f Academician of NAS of Ukraine, Prof., Dr.Sci.(Med.)

Honored Worker of Science and Technology of Ukraine
Laureate of the State Prize in Science and Technology of Ukraine
Laureate of the R.E. Kavetsky Award of NAS of Ukraine

Director of the R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv

Head of the Department of Monitoring of Tumor Process and Therapy Design

Tel +38 (044) 259-01-83

Fax +38 (044) 258-16-56

E-mail chekhun@onconet.kiev.ua


Research interests

  • Screening, preclinical and clinical studies of biologically active anticancer compounds
  • Study of molecular mechanisms of natural and acquired resistance of tumor cells in vitro and in vivo
  • Studies of cytomorphological and ultrastructural effects of antitumor drugs
  • Nanosystems of target transport in cancer: molecular mechanisms of interaction and transformation in biological systems
  • Molecular epidemiology of metal-containing proteins in normal and transformed cells and their role in tumor and host interactions

Key words

  • drug resistance, molecular markers, nanotechnologies in oncology, individualization of antitumor therapy
Education
  • 1980 — graduated from the therapeutic faculty of O.O. Bogomoletz Kyiv Medical Institute, Kyiv, Ukraine
  • 1986 — Thesis for the Degree of Doctor of Philosophy (PhD) in medicine in the specialty — oncology «The influence of thiosorbent K-2-9 on toxic and antitumor effects of cis-dichlorodiaminoplatinum in experiment»
  • 1994 — Dissertation for confirmation of the scientific degree of doctor of medical sciences in the specialty — oncology «The role of plasma membranes of normal and tumor cells in the mechanism of realization of cytotoxic effects of platinum coordination compounds»
Activity

Professional activities

  • 1980-1988 — scientist, senior scientist in the Department of Mechanisms of Antitumor Therapy, R.E. Kavetsky Institute of experimental pathology, oncology and radiobiology, NAS of Ukraine, Kyiv, Ukraine
  • 1988-1996 — scientific secretary of R.E. Kavetsky Institute of experimental pathology, oncology and radiobiology, NAS of Ukraine, Kyiv, Ukraine
  • 1992-1993 — Training in the Institute of Oncology and Radiobiology of Vienna University, Vienna, Austria
  • 1997 — Training in Institute of Oncology of Tel-Aviv University, Tel-Aviv, Israel
  • 1997 — Training in Arizona Cancer Center, Tucson, AZ, USA
  • 1996 — up today — Head of the Department of Mechanisms of Antitumor Therapy, Director of R.E. Kavetsky Institute of experimental pathology, oncology and radiobiology, NAS of Ukraine, Kyiv, Ukraine

Scientific-pedagogical activity

Head of the fundamental medicine chair in scientific-pedagogical center «Institute of biology» of Taras Shevchenko Kyiv National University
Supervisor of 5 dissertations on Dr. Sci. and 12 on PhD

Scientific-Methodical and Organizing activity

  • Chairman of the Scientific Council of R.E. Kavetsky Institute of experimental pathology, oncology and radiobiology, NAS of Ukraine
  • Chairman of the Specialized Dissertation Advisory Council in R.E. Kavetsky Institute of experimental pathology, oncology and radiobiology, NAS of Ukraine
  • Head of scientific council on the problem of «Malignant neoplasms» of the NAS of Ukraine
  • Editor-in-Chief of the international scientific journal «Experimental Оncology»
  • Editor-in-Chief of the scientific-practical journal «Oncology»
  • Member of the editorial boards of international journals: «Journal of Experimental & Clinical Cancer Research», «Asian Journal of Cancer», «The Lancet Oncology, Ukrainian Edition», «Ukrainian Radiological Journal», Member of the editorial council of «Voprosy Onkologii» journal
  • Member of the Ukrainian State Awards Committee
  • Deputy Chairman of the section of Ukrainian State Awards Committee for young scientists
  • Membership in organizations: European Association for Cancer Research (EACR) Association of directors of oncological and roentgen-radiological institutes of NIS countries

 

Research interests
  • Screening, preclinical and clinical studies of biologically active anticancer compounds
  • Study of molecular mechanisms of natural and acquired resistance of tumor cells in vitro and in vivo
  • Identifying new markers and targets for pharmacocorrection based on study of genetic and epigenetic mechanisms of cell transformation
  • Defining of elements of system biology as a basis of personalized diagnostics and monitoring the effectiveness of anticancer therapy
  • Molecular epidemiology of metal-containing proteins in normal and transformed cells and their role in tumor and host interactions
  • Nanosystems of target transport in cancer: molecular mechanisms of interaction and transformation in biological systems
  • Testing of nanomaterials in normal and tumor cells in vitro and in vivo, for assessment of risk of their negative impact on human health
Grants
  • NAS of Ukraine (2010-2014) «Development of biodrugs (biomolecules) based on RNA-based technologies for correction of molecular disorders, found in tumor cells» of the target complex interdisciplinary program of the NAS of Ukraine studies «Fundamental basis of molecular and cellular biotechnologies»
  • NAS of Ukraine (2010-2014) «Biological activity and safety of nanomaterials, which might be used in development of vector systems of antitumor drugs » according to state target program «Nanotechnologies and nanomaterials»
  • NAS of Ukraine (2010-2014) «Complex project: Interaction of nanostructural materials with normal and tumor cells, development of delivery methods, safety of their use», which is performed according to target complex program of NAS of Ukraine fundamental studies «Fundamental problems of nanostructural systems, nanomaterials and nanotechnologies»
  • State agency for science, innovations and informatisation of Ukraine (2011-2012) «Development of technology of synthesis of recombinant human granulocyte colony-stimulating factor and a drug on its basis»
  • MOS of Ukraine (2009-2010) «Action of nanocompounds on organism during tumor growth and oxidative stress»
  • MOS of Ukraine (2009-2010) «Molecular mechanisms of breast and ovarian tumors resistance to cytostatic therapy»
  • UNTC (2006-2008) «Studies of biological activity of magnetosensitive nanocapsules on human tumor cell lines of different histogenesis»
  • IOCA (2005-2008) «Interlaboratory comparison of oncogenicity testing results in ovo»
Publications

Number of publications: over 20 monographs, over 600 scientific articles, 70 patents of Ukraine and 20 methodical recomendations

Selected monographs

  1. Chekhun V.F., Lisovenko G.S., Potebnya G.P. Antitumor vaccines: search for optimal solutions. — К.: Intertechnodruk, 2013. — 109 p. (Rus)
  2. Malignant neoplasms of haematopoetic system: Doctor's guide / Eds. V.F. Chekhun, O.V. Ponomariova. — К.: Doctor-Media, 2012. — 590 p. (Rus)
  3. Nanomaterials and nanocomposites in medicine, biology, ecology / Eds. A.P. Shpak, V.F. Chekhun. — К.: Naukova Dumka, 2011. — 444 p. (Ukr)
  4. Biofunctionalization of nanomaterials and nanocomposites: Textbook / P.P. Gorbyk, S.V. Gorobets. M.P. Turelyk, V.F. Chekhun, A.P. Shpak. — Кyiv: Naukova Dumka, 2011. — 294 p. (Ukr)
  5. Oncology. Selected lectures for students and doctors / Ed. V.F. Chekhun — К.: Zdorovya Ukrainy, 2010. — 770 p. (Ukr)
  6. Ceruloplasmin: from biotechnology to clinical application / N.K. Berdynskikh, K.V. Kurischuk, N.M. Lyalyushko, L.S. Ryadska, G.M. Vorobiova, V.F. Chekhun; Ed. V.F. Chekhun. — К., 2006. — 173 p. (Ukr)
  7. Berezhnaya N.M., Chekhun V.F. Immunology of malignant growth / Ed. A.I. Bykorez. — К.: Naukova Dumka, 2005. — 791 p. (Ukr)
  8. Tumors of the breast / L.N. Koritskaya, S.I. Yalkut, V.I. Tarutinov, S.Ya. Karpilovskaya, G.P. Potebnya, V.I. Tsipriyan, I.K. Khayetsky, G.S. Lisovenko, V.F. Chekhun; Ed. V.F. Chekhun. — К.: Kniga Plus, 2003. — 206 p. (Rus)
  9. Berezhnaya N.M., Chekhun V.F. System of interleukins and cancer (new aspects of interaction between tumor and host). — К.: DIA, 2000. — 224 p. (Rus)
  10. Tsipriyan V.I., Yalkut S.I. Nutrition in tumor prophylactics / Ed. V.F. Chekhun. — К.: Kniga plus, 2000. — 147 p. (Rus)
  11. Cytostatic therapy of malignant neoplasms / Eds. G.I. Solyanik, G.I. Kulik, V.F. Chekhun et al. — К., 2000. — 298 p. (Rus)

Selected articles

  1. Manifestation of key molecular genetic markers in pharmacocorrection of endogenous iron metabolism in MCF-7 and MCF-7/DDP human breast cancer cells / V. Chekhun, N. Lukianova, D. Demash et al. // Cell Biol. — 2013. — V. 2, № 4. — P. 217-227.
  2. Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin / V.F. Chekhun, N.Yu. Lukianova, A.P. Burlaka et al. // Int. J. Oncol. — 2013. — V. 43, N 5. — P. 1481-1486.
  3. Changes in genome stability and mitochondrial potential of tumor cells in vivo / V.F. Chekhun, Yu.V. Lozovska, N.Yu.Lukianova et al. // Tsitologia i Genetika. — 2013. — V. 47, № 4. — P. 46-52. (Ukr)
  4. Alteration in lipid composition of plasma membranes of sensitive and resistant Guerin carcinoma cells due to the action of free and liposomal form of cisplatin / V.F. Chekhun, L.A. Naleskina, I.N. Todor et al. // Exp. Oncology. — 2013. — V. 35, N 3. — P. 192-197.
  5. Evaluation of biological effects of nanosystems of directed transport in experiments in vivo and their application possibilities in anti-tumor therapy / V.F. Chekhun, L.A. Naleskina, L.Z. Polischuk et al. // Advances in Nanoparticles. — 2013. — N 2. — P. 145-153.
  6. Evaluation of biological effects and possible mechanisms of action of static magnetic field / V.F. Chekhun, D.V. Demash, L.A. Naleskina // Fiziologichny zhurnal. — 2012. — V. 58, № 3. — P. 85-94. (Ukr)
  7. The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells / I.N. Todor, N.Yu. Lukyanova, V.F. Chekhun // Exp. Oncology. — 2012. — V. 34, N 2. — P. 97-100.
  8. Chekhun V.F. From system biology of cancer to methodology of personalized treatment // Oncology. — 2012. — V. 14, № 2. — P. 84-88. (Rus)
  9. Tumor heterogeneity — dynamical state / V.F. Chekhun, S.D. Sherban, Z.D. Savtsova // Oncology. — 2012. — V. 14, № 1. — P. 4-12. (Rus)
  10. Chekhun V.F. Development of new drug forms based on nanocomposite materials for solution of modern problems in oncology // Nanosystems, nanomaterials, nanotechnologies: Article book. — К. — 2011. — V. 9, № 1. — P. 261-274. (Ukr)
  11. Chekhun V.F. Nanotechnologies in oncology: perspectives of development and unseen difficulties // The Lancet Oncology, Ukrainian Edition. — 2010. — № 4 (14). — P. 2-3 (Rus)
  12. Chekhun V.F. The concept «Tumor and Host» in the post-genomic era // Exp. Oncology. — 2010. — Vol. 32, N 3. — P. 120-124.
  13. Chekhun V.F., Shpilevaya S.I. Role of endogenous iron in formation of tumor sensitivity to antitumor therapy // Voprosy Onkologii . — 2010. — V. 56, № 3. — P. 251-261 (Rus)
  14. Сhekhun V.F. Stroma — regulation of cancer cell progression // Exp. Oncology. — 2009. — Vol. 31, N 3. — P. 126.
  15. The use of nanoferromagnetic to increase the cytotoxic effect of antitumor drugs / V.F. Chekhun, I.N. Todor, N.Yu. Lukyanova et al. // Exp. Oncology. — 2009. — Vol. 31, N 3. — P. 163-167.
  16. Chekhun V.F. Inflammation and cancer // Oncology. — 2009. — V. 11, № 4. — P. 244-245. (Rus)
  17. Chekhun V.F. Metastasis — Quo vadis? // Exp. Oncology. — 2009. — Vol. 31, N 2. — P. 66.
  18. Chekhun V.F. Tumor stem cells // Oncology. — 2009. — V. 11, № 1. — P. 4-5. (Rus)
  19. Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin / O. Kovalchuk, J. Filkowski, J. Meservy, Ya. Ilnytskyy, V. Tryndyak, V. Chekhun, I. Pogribny // Mol. Cancer Therapy. — 2008. — Vol. 47, № 7. — P. 2152-2159.
  20. Chekhun V.F. Tumor hypoxia and malignant progression // Exp. Oncology. — 2008. — Vol. 30, N 4. — P. 258.
  21. Chekhun V.F. Cancer epigenetics // Exp. Oncology. — 2008. — Vol. 30, N 3. — P. 170.
  22. Chekhun V.F. Antitumor vaccines // Oncology. — 2008. — V. 10, № 2. — P. 204-205. (Rus)
  23. Chekhun V.F. Nanotechnologies in oncology: present and future // Oncology. — 2008. — V. 10, № 1. — P. 7-9. (Rus)
Awards
  • «Order of Merit» (III grade) on the occasion of the 95th anniversary of the NAS of Ukraine, 2013
  • Laureate of State Prize in science and technology of Ukraine «Development of technology for ceruloplasmin and study of its biological and pharmacological properties», 2007
  • Medal «Independence of Ukraine» from International Presidium Rating «Golden Fortune», 2006
  • Honoured Worker of Science and Technology of Ukraine, 2005
  • Diploma of the Verkhovna Rada of Ukraine with honors, 2004
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